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Residents say they are concerned about plans for a warehouse and the traffic and noise issues they say it could cause.
Gompels Healthcare Ltd, a family-run wholesaler, has applied for permission to build a new site near Bath Road in Melksham, Wiltshire.
About 400 people have commented on the application on Wiltshire Council's website, with the majority opposing the plans. Resident Michelle McAlinden said it will bring "more traffic and noise, and make life worse for people who live nearby".
But a Gompels' spokesperson said the building would be "far less disruptive than a housing development".